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Four new tools that have been realized within the framework of the EngCaBra project were selected as demonstrator. Three of the four demonstrators give new insights in cancer diagnoses and therapy. The fourth demonstrator is for investigation of brain diseases. The demonstrations took place during the last EngCaBra project meeting on  February 24, 2015 in Bremen.

 

The Biopsy meter, an infrared absorbance based sensor system to assist pathologists in diagnosing suspicious biopsies and reducing the amount of false positives and false negatives, was demonstrated by Valeria Fioravanti. It was shown on patient biopsies that the biopsy meter can clearly distinguish cancerous regions from the surrounding normal (noncancerous) tissue. This method is highly promising for practical use, because the pathologist can compare the cancerous areas with the normal areas in one measurement. Photos of the demo are shown here:

 

Demonstrator_Valeria

 

Rene Splinter showed a cancer diagnosis system, Fast DSC (differential scanning calorimetry), that monitors the denaturation of proteins present in liquid samples. Blood plasma from patients with cancer shows a difference in heat capacitance compared to blood plasma from healthy individuals. Photos of this live-demonstration are shown below.

 

Demonstrator_Rene

 

Francois Patou showed videos about the SiNW BioFET (Silicon nanowire bio field effect transistor) demonstrator. Functionalised silicon nanowires were used to measure soluble NKG2D ligands derived from blood cancers. The NKG2D receptor (in form of NKG2D-fc fusion protein) was cross-linked to the surface of SiNWs. Purified, soluble NKG2D ligands were then transferred to the SiNW chip. The interaction between soluble NKG2D ligands and NKG2D was recorded by impedance measurements. The chips and some details (including the nanowire) are shown in the photos below.

 

Demonstrator_Francois

 

The fourth demonstrator was shown by Amir Shadmani. He prepared a video about a system comprising a HD-MEA (high-density multiple electrode array) that stimulates and records the communication between neurons in brain slices. The system allows the cultivation of brain slices for long term measurements. Single neuron activity tracing for over 30 days was demonstrated successfully. Below, both the MEA array and the electronics are shown. A video describing this demonstrator can be found here.

 

Demonstrator_Amir