3. Technical University Denmark PDF Print E-mail

Project leader:

Prof. Winnie Svendsen


Involved staff:

Dr. Lars Andresen



Azeem Zulfiqar

Andrea Pfreundt

Francois Patou



The Nano Bio Integrated Systems group at the Technical University of Denmark aims to be a leading authority in integration of micro- and nanoscience in biology. We aim to uncover the physical properties of biological structures in order to learn how to manipulate them in a controlled manner and build lab-on-a-chip systems for their analysis. Our vision is to commercialise our results and create point-of-care medical devices for diagnostics and monitoring. This we will achieve by doing application-based research, tackling known issues and adapting methodologies to micro- and nanotechnology.

The group is working with different kinds of biosensors for the detection of biomolecules with a focus for medical applications.. Apart from the silicon nanowire sensor, an impedance spectroscopy sensor chip for cell measurements and multiplexed protein detection as well as platforms for brain slice culturing and electrochemical monitoring are among the current reseach topics. Within the scope of EngCaBra, the group is responsible for design and fabrication of silicon nanowire field effect transistors, focusing on optimising the existing process sequence for reproducibility and sensitivity. New materials, such as peptide nanowires and tubes as well as graphene sheets are investigated as an alternative to silicon to improve sensitivity even further. Microfluidic systems are an integral part of out research field and constitute the basis for the integration of biosensors for the use as point of care devices. Integrating both biosensor functionalization and automatic sample handling and delivery of physiological fluids such as blood or plasma is a major part of the EngCaBra effort to create a versatile biosensor for cancer diagnostics.