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Current Position

PhD student, Department of Biosystems Science and Engineering (D-BSSE), ETH Zürich

 

Backgroud

M.Sc. Neuroscience, Erasmus University Medical Center Rotterdam, the Netherlands

B.Sc. Neuroscience specialist program, University of Toronto, Scarborough, Canada

 

Supervisors

Prof. Dr. Andreas Hierlemann, ETH Zürich 

Dr. Frederic Knoflach, Hoffmann-La Roche Ltd.

 

Project description

This project aims at growing brain slice cultures on high density multi-electrode array (MEA) chips. Previous studies showed that the hippocampus is important for memory consolidation and retrieval. During awake and dreaming states, different pyramidal cell groups are selectively activated during gamma oscillations depending upon the type of information they encode. However, the selection mechanism is still unclear. Using a high-density MEA, we will be able to record individual pyramidal cell activities at the network level. This research will help to answer questions about selective information processing, and how reduced gamma oscillation synchronization in a model of schizophrenia impacts the selective activation mechanism of pyramidal cells.

Keywords:

HD-MEA, extracellular electrophysiology, organotypic culture, hippocampus, gamma oscillations, data evaluation

 

Collaborations

Hoffmann-La Roche Ltd.

Xensor Delft, The Netherlands


Marie Curie courses:

Courses from Network meeting in Bremen Febuary 2015

Courses from Network meeting in Copenhagen Auguest 2014

Courses from Network meeting in Basel April 2014

Technical University of Denmark, PhD Summer School: Micro- and Nanotechnology for label-free Sensing 2013, August 12-23, 2013

Courses from Network meeting in Delft  September, 2013

Courses from Network meeting in Copenhagen January 2013

Courses from Network meeting in Bratislava and Vienna September 2012

Courses from Network meeting in Basel March 2012

 

Other Courses:

SfN short course III: Optimizing Experimental Design for High-Quality Science, Chicago, IL, USA, 2015

Bench to Bedside symposium 2015, Neuroscience Network Basel, Feb.13, 2015.

Neuroscience cycle B4: Neurological Diseases, University of Basel, Feb-May, 2015

Neuroscience cycle B3: Genes and Behavior, University of Basel, Sep-Dec, 2014

Neuroscience cycle B2: synapse, University of Basel, Feb-May, 2014

Practical course in advanced 3D microscopy Winter School 2014, University of Zürich and ETH Zürich, Jan. 2014

Advanced Neuroscience I, University of Zürich, 2013 - 2014

Microsensors and Microsystems, ETH Zürich, 2012-213

Genetic Approaches in Biomedical Research, University Basel, 2012

Fundamentals of Modern Statistics, ETH Zürich, 2012

Felasa LTK Module 1, 2012

 

Other Trainings:

Project Management (PM) for Research, ETH Zürich, 2015

How does my personal life model influence my career? ETH Zürich HR department, June 16-17, 2015

Learning to Teach Workshop, ETH Zürich, March 2014;

BioBusiness summer school, Amsterdam, the Netherlands, June, 2014

 

Secondments

2014: July, Oct. at Hoffmann-La Roche Ltd.

2013: Feb 4-7, 18-20, March 5-7, 11-13; May 6-8, 13-17, June 3-7, 10-12, July 16 – 18, 23-25, Oct. 1-22, at Hoffmann-La Roche Ltd. 

2012: March 12th - 16th, Aug. 13th - 17th, Oct. 8th -12th at Hoffmann-La Roche Ltd.


Publications

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

 

Conferences

W. GONG, J. SENČAR, D. JÄCKEL, D. BAKKUM, A. HIERLEMANN. "Tracking the activity of multiple individual neurons over one month in organotypic hippocampal slices grown on high-density multi-electrode arrays."  Society for Neuroscience (SfN) Conference, Chicago, IL, USA, 2015, p. 540.08

W. Gong, J. Sencar, D. Jäckel, J. Müller, M. Fiscella, M. Radivojevic, D. Bakkum, A. Hierlemann, "Long-term, High-spatiotemporal-resolution Recording from Cultured Organotypic Slices with High-density Microelectrode Arrays", Proceeedings of the 18th International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers, 2015, Anchorage, Alaska, USA, pp. 1037-1040 (ISBN: 978-1-4799-8954-6, DOI: 10.1109/TRANSDUCERS.2015.7181103).

Wei Gong, Milos Radivojevic, David Jäckel, Douglas Bakkum and Andreas Hierlemann. Long-term, high-spatiotemporal resolution recording and stimulation of hippocampal slice on high-density microelectrode arrays. The 7th International IEEE EMBS Conference on Neural Engineering, 22-24 April 2015, Montpellier, France. Poster presentation.

Wei Gong, David Jäckel, Jan Müller, Michele Fiscella, Milos Radivojevic, Douglas Bakkum, Felix Franke, Frederic Knoflach, Beat Gähwiler, Branka Roscic, Thomas Russell, Andreas Hierlemann (2014). Long-term Cultivation and Recording from Organo-typic Brain Slices on High-density Microelectrode Arrays. MEA Meeting 2014 - 9th international Meeting on Substrate-integrated Microelectrode Arrays, July 1 - 4, 2014 in Reutlingen, Germany

R Splinter, W Gong, A W Van Herwaarden, C Hafner, A Hierlemann.  Poster: Liquid Calorimetry with serum and blood on the Flash DSC1. Lähnwitzseminar on Calorimetry 2014, Germany,June 15-20, 2014

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Shadmani, I.L. Jones, W. Gong, M. Fiscella, M. Radivojevic, D. Bakkum, A. Stettler, F. Heer, A. Hierlemann. Conference Paper: A 1024-channel CMOS microelectrode-array system with 26'400 electrodes for recording and stimulation of electro-active cells in-vitro. Conference: VLSI Circuits (VLSIC), 2013 Symposium 

MEA meeting 2012, Reutlingen, Germany

 

Network Meetings 

Bremen, Germany, Feb. 23-24, 2015

Copenhagen, Danmark, Aug. 25-28, 2014

Basel, Switzerland, April 18-21, 2014

Delft, the Netherlands, Sep 23-26, 2013

Copenhagen, Danmark, Jan 14-18, 2013

Vienna, Austria, September 25-26, 2012

Basel, Switzerland, March 26-27, 2012

 

Industry meetings

Roche visit,  and Siemens “Project management lecture”, April 2012, Basel

 

Memberships

EngCaBra

MEA

Neuroscience Network Basel

FENS

Dutch Neurofederation

BCI

Heart and Stroke Foundation

 

Links

BEL, D-BSSE, ETH Zurich


 
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