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Daniela Pucciarelli PDF Print E-mail

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  Starting 11.07.2011


Background

B. Sc.: Molecular Biology (University of Pisa, Italy)

M. Sc.: Biotechnology (University of Pisa, Italy)

 

Project description

The chondroitin sulfate proteoglycan 4 (CSPG4) and the mutant V600E B-Raf kinase are two of the most important tumor markers in melanoma. The aim of this study is to combine the BRAF inhibitor PLX4032 with anti-225D9+-TT Abs (polyclonal Abs directed against the epitope on the CSPG4) in order to prevent or delay the development of acquired resistance of melanoma BRAF(V600E)/CSPG4+ cells to PLX4032. We hypothesized that targeting multiple signaling pathways would be more effective in suppressing the growth of BRAF V600E mutant melanoma cells.

 

Publications

Sander van den Driesche, Filippo Iuliano, Christoph Haiden, Daniela Pucciarelli, Heimo Breiteneder, Silvia Pastorekova, Christine Hafner, Michael J. Vellekoop, Cell membrane morphology analysis using an infrared sensor system, Sensors and Actuators-B: Chemical journal, 2012.

Pucciarelli D, Weber E, van den Driesche S, Vellekoop MJ, Breiteneder H, Hafner C.
Macromolecular changes in melanoma cells observes by a mid-infrareded sensor system after treatment with Vemurafenib. Journal of Investigative Dermatology , 2013, 133, S238-S238

 

Conferences

27.09.2011       2nd Retreat of the Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna.

13-14.06.2012 YSA-PhD Symposium, Medical University of Vienna.

18.09.2012      3rd Retreat of the Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna.

8-11.05.2013    International Investigative Dermatology 2013, Edinburgh.

19-20.06.2013 YSA-PhD Symposium, Medical University of Vienna.

17.09.2013       4th Retreat of the Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna.

10-13.10.2013     2nd Meeting of Middle-European Societies for Immunology and Allergology, Opatija, Croatia.

5-9.04.2014 Annual Meeting of the American Association for Cancer Research, San Diego, California, USA.

 

Oral Presentation

11-12.6.2014The Response to Vemurafenib is influenced by hypoxia in V600E Mutant Melanoma Cells, Young Scientist Association-PhD Symposium, Medical University of Vienna, Vienna, Austria.


Award: travel bursary, sponsored by European Federation of Immunological Societies (EFIS), for the participation at the upcoming 2nd Meeting of Middle European Societies for Immunology and Allergology in Opatija 2013

 

Secondments

Technical University of Vienna, Vienna, September 2011 - ongoing.

Slovak Academy of Sciences, Slovakia, March 11, 2013 - April 5, 2013.

Slovak Academy of Sciences, Slovakia October 2, 2013 - October 31, 2013

Slovak Academy of Sciences, Slovakia December 10, 2013 - December 19, 2013

Slovak Academy of Sciences, Slovakia January 20, 2014 - February 8, 2014

 

Collaborations

University of Bremen, Germany

Copenhagen University (Health), Denmark

Slovak Academy of Sciences, Slovakia

Xensor Integration BV, Netherlands

 

Summer School: Micro and Nanotechnology for Label-free Sensing 2013, Copenhagen, 12.08.2013-23.08.2013

 

Home institution visit – Invited talk: Melanoma: Targeted Therapy and a New Detection System.

                                            Institute of Clinical Physiology, Consiglio Nazionale Ricerca, Pisa, Italy, April 16, 2013

 

Courses

EngCaBra

Courses from Network meeting in Basel March 2012

Courses from Network meeting in Bratislava and Vienna September 2012

Courses from Network meeting in Copenhagen January 2013

Courses from Network meeting in Delft September 2013

Courses from Network meeting in Basel March 2014


Medical University of Vienna

Basic Seminar: Malignant Diseases I

Propedeutics: Ethics in Medicine and Good Scientific

Propedeutics: Intellectual property rights and project management

Creative and critical Journal Club II

Thesis Seminar: In vitro Methods in Cancer Research

Thesis Seminar: In vitro Analysis of Mechanisms of Cancer Therapeutics

Propedeutics: Methods in Cellular Biology

Propedeutics: Scientific Software and Databases

Creative and critical Journal Club III

Basic Seminar: Malignant Diseases II

Creative and critical Journal Club IV

PhD Symposium

Propedeutics: Linking Biology and Deseases


Network Meetings

Bratislava, Slovakia, September 19, 2011

Basel, Switzerland, March 26-27, 2012

Vienna, Austria, September 25-26, 2012

Copenhagen, Denmark, January 14-17, 2013

Delft, Netherlands, September 23-26, 2013

Basel, Switzerland, March 18-21, 2014

 

Industry Meeting
Basel, March 26-29, 2012
Delft, Nederland, September 23-26, 2013
Basel, March 20-21,2014
 
tanning injections